Status:
TERMINATED
Effects of Intense Aerobic Exercise on the Cerebrovascular Reserve Capacity in Patients With Hemodynamically Relevant Intra- and Extracranial Stenoses
Lead Sponsor:
Gerhard Jan Jungehuelsing
Collaborating Sponsors:
German Federal Ministry of Education and Research
Conditions:
Stenosis
Eligibility:
All Genders
18-80 years
Phase:
NA
Brief Summary
The purpose of this trial is to study the improvement of cerebral hemodynamics in high risk stroke patients with impaired Cerebrovascular Reserve (CVR) due to high grade stenosis of the internal carot...
Detailed Description
The primary objective: Intense aerobic exercise (24/8 weeks) improves CVR \> 20% measured by Transcranial Doppler (TCD) in patients with hemodynamic relevant intra- or extracranial stenoses by enhance...
Eligibility Criteria
Inclusion
- high-grade stenosis of the intra- or extracranial ICA or the MCA with ipsilateral impairment of the CVR capacity measured by TCD
Exclusion
- continuous physical activity ≥ 60 min/week within the last 3 months
- cerebral bleeding or ischaemic stroke \< 3 months
- contraindications for spiro-ergometry, IAEx, or MRI
Key Trial Info
Start Date :
June 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2012
Estimated Enrollment :
50 Patients enrolled
Trial Details
Trial ID
NCT00912561
Start Date
June 1 2009
End Date
December 1 2012
Last Update
February 22 2012
Active Locations (1)
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1
Centre for Stroke Research Berlin, Neurology, Charité Campus Benjamin Franklin
Berlin, Germany, 12200