Status:
COMPLETED
Cholinergic Augmentation in Frequently Falling Subjects With Parkinson's Disease
Lead Sponsor:
Oregon Health and Science University
Conditions:
Parkinson's Disease
Eligibility:
All Genders
21+ years
Phase:
NA
Brief Summary
The purpose of this study is to find out if a medication that increases levels of a brain chemical called acetylcholine will improve balance and reduce falls in patients with parkinson's disease who h...
Detailed Description
This trial is a double-blinded cross-over design comparing donepezil with placebo in 40 subjects with idiopathic Parkinson's disease who report frequent falls or near falls (\>2/week). The purpose of ...
Eligibility Criteria
Inclusion
- Age over 21
- Diagnosis of Parkinson's disease
- Treated with dopaminergic medication for at least 1 year
Exclusion
- Must be ambulatory (can use walker or cane)
- No obvious remediable cause of falls
- Falls are on basis of non-CNS etiologies (cardiogenic, orthopedic, peripheral neuropathy, etc)
- Dementia present (MMSE \< 25)
- Not taking cholinergic or anticholinergic medications 10 days prior to screening visit
- No Warfarin use
Key Trial Info
Start Date :
October 1 2005
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
February 1 2009
Estimated Enrollment :
23 Patients enrolled
Trial Details
Trial ID
NCT00912808
Start Date
October 1 2005
End Date
February 1 2009
Last Update
May 8 2018
Active Locations (0)
Enter a location and click search to find clinical trials sorted by distance.
No Results Found
We couldn’t find results for the location/zipcode entered or within the selected range. Please check your input or adjust your search.