Status:
TERMINATED
Liver Regeneration Therapy Using Autologous Adipose Tissue Derived Stromal Cells
Lead Sponsor:
Kanazawa University
Conditions:
Liver Cirrhosis
Eligibility:
All Genders
20-80 years
Phase:
PHASE1
Brief Summary
Mesenchymal stem cells have the capability to differentiate into hepatocytes and will be useful for liver regeneration. Adipose tissue is relatively enriched with mesenchymal stem cells compared to bo...
Detailed Description
The population of the liver cirrhosis patients is enormous in Japan and the only radical treatment for them is liver transplantation. However, the number of giving donors is extremely limited. Mesench...
Eligibility Criteria
Inclusion
- Liver cirrhosis patients
- Platelets count in peripheral blood: over 7.0x10\^4/microliter
- Serum creatinine: less than 1.5 mg/dl
- Capable of understanding the features of this clinical trial
Exclusion
- Associated with risky gastroesophageal varices for bleeding
- Severe portal hypertension
- Complicated with severe heart failure
- Renal disease
- Respiratory disease
- Hematological disease
- Coagulation disturbance and judged to be excluded by doctors
- Associated with malignancy
- Past history of the following:
- malignancy
- ischemic heart disease
- cerebrovascular disease (cerebral infarction, cerebral hemorrhage)
- decompensated status of liver cirrhosis
- Pregnant, or possibility of pregnancy
- Infected with HIV
- Under mediation with adrenal corticoid steroid, anti-histamine drug
- Anticipated with difficulty of follow-up observation
- Anticipated with inconsistency of following the protocol
- Addiction of alcohol drinking and unable to stop drinking
- Other candidates who are judged to be not applicable to this study by doctors
Key Trial Info
Start Date :
February 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
April 1 2010
Estimated Enrollment :
6 Patients enrolled
Trial Details
Trial ID
NCT00913289
Start Date
February 1 2009
End Date
April 1 2010
Last Update
October 18 2012
Active Locations (1)
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1
Kanazawa University Hospital
Kanazawa, Ishikawa-ken, Japan, 920-8641