Status:
COMPLETED
A Functional Magnetic Resonance Imaging (fMRI) Study in Overweight and Obese Men (0000-103)
Lead Sponsor:
Merck Sharp & Dohme LLC
Conditions:
Obesity
Eligibility:
MALE
18-45 years
Phase:
PHASE1
Brief Summary
This study will determine whether BOLD-fMRI can be used to probe hunger and satiety states in healthy overweight or obese men and also whether fasted/fed fMRI signals can be modulated by sibutramine.
Eligibility Criteria
Inclusion
- Subject is a male between 18 and 45 years of age
- Subject has a body mass index (BMI) between 28 and 35 kg/m\^2
- Subject does not weigh more than 140 kg (309 lbs) at the screening visit
- Subject is right-handed
- Subject is a non-smoker
- Subject is in generally good health
- Subject has normal or corrected to normal vision
Exclusion
- Subject works a night shift within 3 days of each treatment visit
- Subject has permanent cosmetic or metallic objects in his body
- Subject has attention deficit hyperactivity disorder (ADHD)
- Subject has or had sleep apnea
- Subject has a history of neurological disorders
- Subject has a history of any clinically significant disease or condition
- Subject is vegan or vegetarian
- Subject has a history of eating disorders
- Subject has had previous bariatric surgery
Key Trial Info
Start Date :
May 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 1 2009
Estimated Enrollment :
15 Patients enrolled
Trial Details
Trial ID
NCT00914212
Start Date
May 1 2009
End Date
August 1 2009
Last Update
October 12 2015
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