Status:
WITHDRAWN
Diesel Exhaust Particles and Leukotriene Production
Lead Sponsor:
University of California, Los Angeles
Collaborating Sponsors:
Merck Sharp & Dohme LLC
Conditions:
Allergic Rhinitis
Eligibility:
All Genders
18-65 years
Brief Summary
The purpose of this study is to measure the effects of allergens and/or diesel exhaust particles in the nose to learn more about allergic responses in individuals with cat allergic rhinitis.
Eligibility Criteria
Inclusion
- Age 18 to 65 years old.
- Positive prick (epicutaneous) skin test to standardized cat with a wheal equal to or greater than 3 mm and with a surrounding flare.
- Ability to give informed consent.
Exclusion
- Pregnancy or breast-feeding. (Pregnancy and the period during breast feeding can affect nasal congestion and be a confounder in this regard.)
- Systemic corticosteroid use within the previous three months or anytime during the challenge protocol.
- Topical nasal corticosteroid use within the past month or anytime during the challenge protocol.
- Systemic antihistamines or decongestant use within past two weeks or anytime during the trial.
- Chronic sinusitis or chronic non-allergic rhinitis.
- Use of reserpine.
- Cigarette smoking within the past year or during the challenge protocol
- Use of topical nasal antihistamines, chromoglycolates (chromolyn, Cromlon®), decongestants or non-steroidal anti-inflammatory agents (NSIADS) within the preceding week or anytime during the challenge protocol.
- Present or treatment within the past 10 years with allergy immunotherapy (injections).
- Present or past treatment with anti-IgE therapy.
- Any unusual exposure to air pollutants (e.g., working as a diesel mechanic) that, in the opinion of the investigators, might compromise the individual's ability to participate in the study.
- Living arrangement where the subject has a cat dwelling within the subject's habitation.
- Any serious heart, lung, neurological or kidney disease that in the opinion of the investigators would impair the individual's ability to participate in the study.
- Use of asthma-required medications.
Key Trial Info
Start Date :
April 1 2008
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
April 11 2013
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT00915447
Start Date
April 1 2008
End Date
April 11 2013
Last Update
January 23 2019
Active Locations (1)
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1
University of California, Los Angeles
Los Angeles, California, United States, 90095-1680