Status:
COMPLETED
Adjunctive Cilostazol Versus High Maintenance-dose ClopidogrEL in Acute Myocardial Infarction (AMI) Patients According to CYP2C19 Polymorphism
Lead Sponsor:
Gyeongsang National University Hospital
Conditions:
Myocardial Infarction
Eligibility:
All Genders
18+ years
Phase:
PHASE4
Brief Summary
Percutaneous coronary intervention (PCI) with stent implantation is the preferred reperfusion strategy for treatment of acute myocardial infarction (AMI). Despite advances in both devices and pharmaco...
Detailed Description
* Study timeline: Enrollment period - 6 months (2009. 5.- 2009. 10.) (Follow-up period - 1 month after randomization) * Stenting, adjunct drug therapy and markers of myonecrosis 1\) PCI (...
Eligibility Criteria
Inclusion
- The patient must be at least 18 years of age.
- clinical symptoms compatible with acute myocardial ischemia within 12 h before admission with a subsequently documented increase in cardiac markers.
- Measured pre-discharge platelet reactivity in case of normalized CK-MB value after coronary stenting.
Exclusion
- A history of active bleeding and bleeding diatheses.
- Oral anticoagulation therapy with coumadin.
- Contraindication to antiplatelet therapy.
- LV ejection fraction \< 30% or NYHA 3/4.
- Leukocyte count \< 3,000/mm3 and/or platelet count \< 100,000/mm3.
- AST or ALT ≥ 3 times upper normal.
- Serum creatinine level ≥ 2.5 mg/dl.
- Stroke within 3 months.
- Non-cardiac disease with a life expectancy \< 1 year.
- Inability to follow the protocol.
Key Trial Info
Start Date :
May 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
November 1 2009
Estimated Enrollment :
80 Patients enrolled
Trial Details
Trial ID
NCT00915733
Start Date
May 1 2009
End Date
November 1 2009
Last Update
November 10 2009
Active Locations (1)
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1
Gyeongsang National University Hospital
Jinju, South Korea, 660-702