Status:
COMPLETED
Imaging of Vesicular Acetylcholine and Dopamine Transporters in Dementia With Lewy Bodies
Lead Sponsor:
University Hospital, Bordeaux
Conditions:
Dementia With Lewy Bodies
Eligibility:
All Genders
18-90 years
Phase:
NA
Brief Summary
The general aim of this research project is to determine the relationships between alterations of central cholinergic (ACh) and dopaminergic (DA) systems and neurobehavioral features of dementias with...
Detailed Description
Neurochemical investigations and observations suggest a crucial physiopathological role of central ACh systems in dementias with Lewy bodies (DLB). Alterations of cholinergic neurons could be involved...
Eligibility Criteria
Inclusion
- Patients: man or woman probable DLB, with and without extrapyramida syndrome
- Healthy subjects: man or woman with no neuropsychiatric disorders
Exclusion
- Diagnostic or therapeutic irradiation during the 12 months before SPECT imaging
- Age less than 18 and more than 90
- Iodine sensibility
- Brain-vascular disease, severe brain injury, type I and II diabetes mellitus, thyroid dysfunction, chronic alcoholism
- Pregnant and breast feeding women, women in age to procreate
- Impossibility to undergo MRI study (pace-maker, claustrophobia)
- Persons under guardianship, outside state to express their assent or in emergency situation
- Healthy subjects: cognitive impairment, dementia
Key Trial Info
Start Date :
May 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
October 1 2013
Estimated Enrollment :
34 Patients enrolled
Trial Details
Trial ID
NCT00917709
Start Date
May 1 2009
End Date
October 1 2013
Last Update
August 21 2014
Active Locations (1)
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1
Groupe Hospitalier Pellegrin - C.H.U. de Bordeaux
Bordeaux, France, 33076