Status:
COMPLETED
Natural History of Atherosclerosis
Lead Sponsor:
University of Zurich
Collaborating Sponsors:
Districthospital of Bellinzona
Conditions:
Atherosclerosis
Eligibility:
All Genders
Brief Summary
20 patients will be recruited. The aim of the study is to determine the natural progression of atherosclerotic disease.
Eligibility Criteria
Inclusion
- stable carotid artery disease not requiring revascularization
- asymptomatic carotid artery stenosis \< 80% or symptomatic patients with stenosis \< 60 %
- prophylactic therapy with aspirin (\> 100mg/day, statin, blood pressure therapy if indicated (goal \< 130/80 mmHg))
- informed consent
Exclusion
- non atherosclerotic occlusive disease (Bürgers disease)
- uncontrolled BP (DBP \> 110 mmHg and/or SBP \> 200 mmHg)
- hemorrhagic disease or platelet count \< 100'000 mm\^3
- Known active liver disease (elevations of GPT GOT or increased ammonia)
- impaired renal function (crea \> 180 mmol/l)
- pregnancy
- severe claustrophobic reactions
- short - term life - threatening pathology
- physically unable to participate in the study
- compliance not guaranteed
Key Trial Info
Start Date :
January 1 2007
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
March 1 2010
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT00918541
Start Date
January 1 2007
End Date
March 1 2010
Last Update
December 23 2011
Active Locations (3)
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1
Ospedale San Giovanni Bellinzona
Bellinzona, Switzerland
2
Ospedale San Giovanni
Bellinzona, Switzerland
3
Cardiovascular Center Cardiology University Hospital Zürich
Zurich, Switzerland