Status:
TERMINATED
Repetitive Transcranial Magnetic Stimulation (rTMS) in Depression
Lead Sponsor:
Northside Clinic, Australia
Conditions:
Depression
Eligibility:
All Genders
18+ years
Phase:
PHASE4
Brief Summary
This study will report on the outcomes of rTMS administered 3 times per week, compared with the standard protocol of 5 times per week. Participants will be randomly assigned to frequency condition and...
Detailed Description
Numerous studies have demonstrated the efficacy of active rTMS over sham rTMS for depression; however, few have systematically studied the optimal frequency of treatment sessions to achieve this effic...
Eligibility Criteria
Inclusion
- Aged \>/= 18
- DSM-IV diagnosis of Major Depressive Episode (bipolar or MDD)
- MADRS score \>/= 20
- Able to give informed consent
- Psychoactive medication dosages have been stable for a period of 4 weeks prior to entry in the study
Exclusion
- Co-morbid alcohol or drug abuse or dependence (last 3 months), current eating disorder, mental retardation, schizophrenia, rapid cycling bipolar
- A history of mood 'switching' in response to other treatments, which cannot be contained by concurrent treatment, e.g., mood stabiliser
- Pregnancy
- Significant neurological disorder that increases seizure risk
- Metal objects in the head, pacemakers, or a history of epilepsy
- Patients who have failed to respond to a course of ECT in their current episode of depression
- A high risk of suicide
Key Trial Info
Start Date :
May 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
August 1 2011
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT00920322
Start Date
May 1 2009
End Date
August 1 2011
Last Update
July 21 2011
Active Locations (1)
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1
Northside Clinic
Greenwich, New South Wales, Australia, 2065