Status:
WITHDRAWN
A Study to Assess the Pharmacokinetics of Methotrexate Given With and Without AZD9056 in Rheumatoid Arthritis Patients
Lead Sponsor:
AstraZeneca
Conditions:
Rheumatoid Arthritis
Eligibility:
All Genders
18-70 years
Phase:
PHASE1
Brief Summary
The main aim of this clinical study is to investigate whether the blood concentration of methotrexate changes when AZD9056 is co- administered together with methotrexate.
Eligibility Criteria
Inclusion
- Patients diagnosed with rheumatoid arthritis
- Currently on Methotrexate treatment
- Provision of informed consent
Exclusion
- History of malignancy (except for treated squamous and basal cell carcinoma of the skin more than 5 years prior to entry)
- Patients who were taking prescription of medications listed below:
- Medications that are hepatic enzyme inducers and that were inhibitors of cytochrome P450, Lovastatin
- Leflunomide, hydroxychloroquine, cyclosporin or anti-tumour necrosis factor therapies within 90 days of Visit 1, or treatment with rituximab within 1 year before Visit 1
Key Trial Info
Start Date :
May 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
September 1 2009
Estimated Enrollment :
12 Patients enrolled
Trial Details
Trial ID
NCT00920608
Start Date
May 1 2009
End Date
September 1 2009
Last Update
December 3 2010
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