Status:
COMPLETED
A Safety and Efficacy Study of Dimebon in Patients With Huntington Disease
Lead Sponsor:
Medivation, Inc.
Collaborating Sponsors:
Pfizer
Conditions:
Huntington Disease
Eligibility:
All Genders
30+ years
Phase:
PHASE3
Brief Summary
The purpose of this study is to determine if Dimebon is safe and effective for the treatment of cognitive impairment in Huntington disease.
Detailed Description
This study is a multicenter Phase 3, randomized, double-blind, placebo-controlled safety and efficacy study of Dimebon treatment in subjects with Huntington disease (HD). The study will evaluate Dimeb...
Eligibility Criteria
Inclusion
- Have clinical features of HD and a CAG polyglutamate repeat expansion ≥ 36
- Have cognitive impairment as noted by the following:
- A Screening MMSE AND a baseline (pre-dose) MMSE score between 10 and 26 (inclusive); and
- A subjective assessment of cognitive impairment with decline from pre-HD levels by the Investigator after interviewing the subject and caregiver;
- Are willing and able to give informed consent
- Aged 30 years or older
- Have a caregiver who assists/spends time with the subject at least five days per week for at least three hours per day and has intimate knowledge of the subject's cognitive, functional, and emotional states, and of the subject's personal care.
Exclusion
- Had onset of symptoms prior to age 18
- Have any major medical illness or unstable medical condition within 180 days of screening that may interfere with the subject's ability to comply with study procedures and abide by study restrictions, or with the ability to interpret safety data
Key Trial Info
Start Date :
July 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
Estimated Enrollment :
403 Patients enrolled
Trial Details
Trial ID
NCT00920946
Start Date
July 1 2009
Last Update
October 12 2016
Active Locations (37)
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1
Scottsdale, Arizona, United States, 85259
2
Davis, California, United States, 95616
3
Irvine, California, United States, 92697
4
La Jolla, California, United States, 92161