Status:
COMPLETED
Cataract Removal and Alzheimer's Disease
Lead Sponsor:
University Hospitals Cleveland Medical Center
Collaborating Sponsors:
Case Western Reserve University
MetroHealth Medical Center
Conditions:
Cataracts
Alzheimer's Disease
Eligibility:
All Genders
50-90 years
Phase:
NA
Brief Summary
Two very common aging-related diseases in older adults are Alzheimer's disease (AD) and cataracts. In elderly adults, these two diseases frequently occur in the same person. Although a cure for AD is ...
Detailed Description
In this project, we propose to test the following clinical hypothesis, while addressing the primary and two secondary Specific Aims: Hypothesis: Cataract removal produces measurable benefits in visio...
Eligibility Criteria
Inclusion
- age 50 and older
- clinical diagnosis of possible/probable Alzheimer's disease, or other type of dementia, mild (CDR-1), moderate (CDR-2), or severe (CDR-3)
- at least 1 visually significant cataract
- no ocular pathology
- psychotropic drug must be with stable dosage for 30 days
Exclusion
- history of cataract removal
- history of visually significant retinal, or optic nerve abnormalities
- informed consent cannot be obtained from either subject or their research partner
- subject shows evidence (in preoperative testing) of unstable cardiac or pulmonary function
- history of uncontrolled diabetes or hypertension
- history of stroke in areas known to affect cognition
- life expectancy of less than 1 year
- Down's Syndrome
Key Trial Info
Start Date :
June 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 30 2017
Estimated Enrollment :
122 Patients enrolled
Trial Details
Trial ID
NCT00921297
Start Date
June 1 2009
End Date
March 30 2017
Last Update
November 9 2017
Active Locations (2)
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1
University Hospitals Case Medical Center
Cleveland, Ohio, United States, 44106
2
MetroHealth Medical Center
Cleveland, Ohio, United States, 44109