Status:
COMPLETED
Effects of Electroconvulsive Therapy (ECT) on Serotonin-1A Receptor Binding
Lead Sponsor:
Medical University of Vienna
Conditions:
Unipolar Depression
Eligibility:
All Genders
18-60 years
Phase:
PHASE4
Brief Summary
In treatment-resistant depression, electroconvulsive therapy (ECT) has been shown to effectively reduce depressive symptoms, though the underlying neurobiological mechanism is still unclear. The serot...
Eligibility Criteria
Inclusion
- Male or female
- Age 18 - 65 years
- ICD-10 diagnosis of severe unipolar depression (ICD-10: F32.2, F32.3; F33.2, F33.3)
- A score of 23 or greater on the 17-item HAM-D
- Signed informed consent form
- Negative urine pregnancy test in women at the screening visit and at PET days
- Antidepressive and antipsychotic medication in a steady state for at least 10 days prior to inclusion
- Anesthesiological approval for ECT
Exclusion
- Concomitant major internistic or neurological illness
- Clinically relevant abnormalities on a general physical examination and routine laboratory screening
- Current substance abuse, addiction
- Current or past history of schizophrenia or schizoaffective disorder
- Exposure to artificial radiation as volunteer in clinical studies within 10 years prior to inclusion into the present study
- Previous treatments with electroconvulsive therapy
- Treatment (\< 1 months before screening) with the following drugs: Aripiprazole, Risperidone, Ziprasidone, Clozapine, Chlorpromazine, Amitryptyline, Nefazodone, Trazodone, Buspirone, Pindolol, Penbutolol, Tertatolol, Alprenolol, Quetiapine
- Investigations using PET or SPECT within 10 years prior to the inclusion
Key Trial Info
Start Date :
June 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 1 2011
Estimated Enrollment :
12 Patients enrolled
Trial Details
Trial ID
NCT00922064
Start Date
June 1 2009
End Date
September 1 2011
Last Update
November 16 2011
Active Locations (1)
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1
Medical University of Vienna, Dept. of Psychiatry and Psychotherapy
Vienna, Vienna, Austria, 1090