Status:
RECRUITING
Natural History Study of Monoclonal B Cell Lymphocytosis (MBL), Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL), Lymphoplasmacytic Lymphoma (LPL)/Waldenstrom Macroglobulinemia (WM), and Splenic Marginal Zone Lymphoma (SMZL)
Lead Sponsor:
National Heart, Lung, and Blood Institute (NHLBI)
Conditions:
Waldenstrom Macroglobulinemia
Lymphoplasmacytic Lymphoma
Eligibility:
All Genders
18-110 years
Brief Summary
Background The development of new technologies now allow scientists to investigate the molecular basis and clinical manifestations of monoclonal B cell lymphocytosis (MBL), chronic lymphocytic leukem...
Detailed Description
The purpose of this protocol is to collect blood, tissue (bone marrow and lymph node biopsies) and/or imaging studies (PET and CT scans) from patients with monoclonal B cell lymphocytosis (MBL), chron...
Eligibility Criteria
Inclusion
- INCLUSION CRITERIA:
- Diagnosis of CLL/SLL will be made according to the updated criteria of the NCI Working Group.
- on treatment or previously treated
- requiring or nearing first-line treatment
- OR
- Diagnosis of LPL/WM. LPL is defined as the presence of an intertrabecular pattern of bone marrow infiltration by small lymphocytes showing plasmacytoid/plasma cell differentiation. WM, comprising \>95% of LPL cases, describes the clinical syndrome of LPL associated with an IgM monoclonal gammopathy of any concentration. The remaining cases may be IgA, IgM, or non-secreting LPL. Immunophenotyping is required for diagnosis
- Age greater than or equal to 18 years.
- ECOG performance status of 0-2.
- Able to comprehend the investigational nature of the protocol and provide informed consent
- EXCLUSION CRITERIA:
- 1\. None
Exclusion
Key Trial Info
Start Date :
May 29 2008
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
Estimated Enrollment :
1000 Patients enrolled
Trial Details
Trial ID
NCT00923507
Start Date
May 29 2008
Last Update
October 16 2025
Active Locations (1)
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1
National Institutes of Health Clinical Center
Bethesda, Maryland, United States, 20892