Status:
COMPLETED
The Use of Neuromuscular Electrical Stimulation to Reverse Muscle Atrophy in Patients With Rheumatoid Arthritis
Lead Sponsor:
University of Pittsburgh
Conditions:
Rheumatoid Arthritis
Eligibility:
All Genders
21+ years
Phase:
NA
Brief Summary
This study will be a small randomized clinical trial to test the effectiveness of neuromuscular electrical stimulation (NMES) to improve physical function and reverse muscle atrophy in patients with r...
Eligibility Criteria
Inclusion
- English-speaking
- Age 21 or older
- Diagnosed with RA for at least 5 years according to the criteria of the American College of Rheumatology
- Independent ambulator
Exclusion
- History of cardiovascular disease or uncontrolled hypertension (above 140/90 mmHg);
- History of a quadriceps tendon or patellar tendon rupture;
- History of previous adverse reaction associated with electrical stimulation treatment;
- Surgery to the dominant lower extremities within the past 6 months.
- History of a neurological disorder that may affect lower extremity function, such as cerebrovascular accident or neuropathy, parkinson's disease, multiple sclerosis, etc.;
- History of muscle disease such as muscular dystrophy;
- Change in medication regimen (excluding NSAID change) during the month prior to treatment;
- Current use of cholesterol-lowering medication;
- History of malignancy during the last 5 years, excluding skin cancers other than melanoma;
- Current or anticipated pregnancy;
- Less than 70º of passive knee flexion;
- Are not willing to undergo needle biopsy.
- Participated in progressive resistance training or NMES training in the prior year;
- Prior adverse effects with local anesthesia.
Key Trial Info
Start Date :
June 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
February 1 2014
Estimated Enrollment :
64 Patients enrolled
Trial Details
Trial ID
NCT00924625
Start Date
June 1 2009
End Date
February 1 2014
Last Update
September 10 2014
Active Locations (1)
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1
Physical Therapy Department
Pittsburgh, Pennsylvania, United States, 15260