Status:
COMPLETED
A Study of Inhalation of 20,000 EU CCRE and Mucociliary Clearance (MCC) in Otherwise Healthy Individuals Who Are Current Cigarette Smokers
Lead Sponsor:
University of North Carolina, Chapel Hill
Conditions:
Healthy
Cigarette Smoking
Eligibility:
All Genders
18-50 years
Phase:
PHASE1
Brief Summary
The purpose of this Phase 1 research study is to identify a dose of inhaled endotoxin that is safe (does not cause prolonged cough, shortness of breath or other problems), but causes changes in sputum...
Detailed Description
The purpose of this study is to determine the range of neutrophil response (influx of PMNs to the airways as determined in sputum) after inhalation of CCRE (20,000 EU), shown in previous studies of he...
Eligibility Criteria
Inclusion
- Must be current cigarette smokers
- Must be otherwise healthy
- Must be good sputum producers
Exclusion
- Any acute illness any chronic illness which would impact results
Key Trial Info
Start Date :
May 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 1 2012
Estimated Enrollment :
12 Patients enrolled
Trial Details
Trial ID
NCT00924768
Start Date
May 1 2009
End Date
June 1 2012
Last Update
August 6 2013
Active Locations (1)
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1
UNC Center for Environmental Medicine, Asthma and Lung Biology
Chapel Hill, North Carolina, United States, 27599