Status:
COMPLETED
The Role of Factor XIII Activation Peptide and D-dimer Values for the Diagnosis of Cerebral Venous Thrombosis (CVT)
Lead Sponsor:
Insel Gruppe AG, University Hospital Bern
Collaborating Sponsors:
Schweizerische Herzstiftung
Conditions:
Cerebral Venous Thrombosis
Eligibility:
All Genders
18-85 years
Brief Summary
The investigators aim to assess the overall accuracy of D-dimer values and FXIII activation peptide (FXIII-AP), using a newly developed ELISA test, to exclude CVT in patients with clinical suspicion o...
Detailed Description
Background Because of the broad clinical spectrum it is often difficult to establish the diagnosis of cerebral venous thrombosis (CVT). Combined MRI/MRV and contrast-enhanced CT are the most accurate...
Eligibility Criteria
Inclusion
- Inclusion Criteria:
- Adults with clinical suspicion of CVT
- Isolated unexplained headache of less than 30 days duration
- Headache associated with focal central neurological deficits of less than 30 days duration
- Headache associated with disturbed consciousness of less than 30 days duration
- Headache associated with epileptic seizures of less than 30 days duration
- Unexplained papilledema of less than 30 days duration
- Exclusion Criteria
- Deep venous thrombosis within 3 months prior to admission
- Pulmonary embolism within 3 months prior to admission
- Ischemic stroke within 3 months prior to admission
- Myocardial infarction within 3 months prior to admission
- Other vascular disease within 3 months prior to admission
- Headache due to trauma
- Malignant neoplasia
- Treatment with anticoagulants prior to admission
Exclusion
Key Trial Info
Start Date :
September 1 2009
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
December 31 2017
Estimated Enrollment :
401 Patients enrolled
Trial Details
Trial ID
NCT00924859
Start Date
September 1 2009
End Date
December 31 2017
Last Update
October 12 2018
Active Locations (2)
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1
Department of Neurology, Academic Medical Centre, University of Amsterdam
Amsterdam, Netherlands, 1100
2
Dep. of Neurology, Bern University Hospital
Bern, Switzerland, 3010