Status:
UNKNOWN
Gene Expression Profile of Breast Cancer Samples After Vitamin D Supplementation
Lead Sponsor:
University of Sao Paulo General Hospital
Collaborating Sponsors:
Instituto Brasileiro de Controle do Cancer
Conditions:
Breast Neoplasms
Postmenopausal Disorder
Eligibility:
FEMALE
40-70 years
Phase:
NA
Brief Summary
The purpose of this study is to evaluate whether calcitriol supplementation may reduce tumor cell proliferation and influence gene expression profile of breast cancer samples from post-menopausal pati...
Detailed Description
Women affected by breast cancer present lower 1,25(OH)2D3 or 25(OH)D3 serum levels than unaffected ones. Calcitriol supplementation may be indicated to post-menopausal women to reduce bone loss. Vitam...
Eligibility Criteria
Inclusion
- Postmenopausal women
- Invasive breast carcinoma
- Clinical conditions for breast surgery
- No previous neoadjuvant treatment for breast cancer
- Agreement to take part in the study and sign the informed consent
Exclusion
- History of hypercalcemia or nephrolithiasis
- Current use of corticosteroids, vitamin D supplementation, HRT
- Previous chemotherapy, hormonotherapy or radiotherapy
- Parathyroid disease
- Absence of clinical condition to receive supplementation
Key Trial Info
Start Date :
July 1 2007
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2013
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT00926315
Start Date
July 1 2007
End Date
December 1 2013
Last Update
November 1 2012
Active Locations (1)
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1
Instituto Brasileiro de Controle do Câncer - IBCC
São Paulo, São Paulo, Brazil, 03102-002