Status:
COMPLETED
Assessing Anterior Cingulate Brain Activity in People With Late-Life Depression
Lead Sponsor:
Weill Medical College of Cornell University
Conditions:
Depression
Eligibility:
All Genders
60-85 years
Brief Summary
This study will examine differences in activity of the anterior cingulate cortex, a brain area involved in emotion and cognitive regulation, between older adults with and without depression.
Detailed Description
Older adults with depression often also suffer from executive dysfunction-problems with planning, impulse control, and reasoning. Executive dysfunction in older adults predicts poor or delayed respons...
Eligibility Criteria
Inclusion
- Inclusion Criteria for Depressed Participants:
- Diagnosis of major depression by DSM-IV criteria
- Mini-Mental State Examination (MMSE) score greater than 24
- Severity score of 17 or higher on the 21-item Hamilton Depression Rating Scale score (HDRS) during the index episode
- Residence less than a 45-minute drive from New York Hospital-Westchester Division
- Exclusion Criteria for Depressed Participants:
- Presence of psychotic depression, as defined by Research Diagnostic Criteria and DSM-IV
- History of psychiatric disorders other than unipolar major depression (people with bipolar disorder and dysthymia will be excluded)
- Presence of dementing disorders
- Acute or severe medical illness, such as the following: delirium; metastatic cancer; decompensated cardiac, liver, or kidney failure; major surgery; or cerebrovascular accident or myocardial infarction 3 months prior to study entry
- Receiving drugs known to cause depression, including reserpine, alpha-methyl-dopa, and steroids
- Requires concomitant treatment with other psychotropics, including antipsychotic medications, lithium salts, stimulants, valproic acid, carbamazepine, or gabapentin
- Severe aphasia interfering with communication
- Contraindications to magnetic resonance (MR) scanning, such as implanted metal, claustrophobia, or weight greater than or equal to 300 lbs
- Inclusion Criteria for Age-Matched Non-Psychiatric Comparison Sample:
- MMSE score greater than 24
- Exclusion Criteria for Age-Matched Non-Psychiatric Comparison Sample:
- History of psychiatric disorder
- Presence of dementing disorders
- Acute or severe medical illness, such as the following: delirium; metastatic cancer; decompensated cardiac, liver, or kidney failure; major surgery; or cerebrovascular accident or myocardial infarction 3 months prior to study entry
- Receiving drugs known to cause depression, including reserpine, alpha-methyl-dopa, and steroids
- Current treatment with psychotropics
- Severe aphasia interfering with communication
- Contraindications to MR scanning, such as implanted metal, claustrophobia, or weight greater than or equal to 300 lbs
Exclusion
Key Trial Info
Start Date :
July 1 2005
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
May 1 2010
Estimated Enrollment :
76 Patients enrolled
Trial Details
Trial ID
NCT00926653
Start Date
July 1 2005
End Date
May 1 2010
Last Update
August 11 2015
Active Locations (1)
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1
New York Presbyterian-Weill Cornell Medical College
White Plains, New York, United States, 10605