Status:
COMPLETED
Effects of Ethanol on Intestinal Permeability and Integrity
Lead Sponsor:
Maastricht University Medical Center
Collaborating Sponsors:
Top Institute Food and Nutrition
Conditions:
Healthy
Eligibility:
MALE
18-45 years
Phase:
NA
Brief Summary
Alcohol consumption is a major health problem worldwide. It affects all systems of the body especially the gastrointestinal tract. Acute or chronic alcohol consumption has deleterious effects on the g...
Eligibility Criteria
Inclusion
- Signed informed consent form.
- Male gender to avoid the gender-related differences in ethanol metabolism.
- Between 18-45 years to avoid age-related changes in ethanol metabolism39.
- Normal medical history and physical examination.
- Normal liver function tests (i.e. ALT, AST, and γGT) according to the reference values for normal ranges of the liver enzymes at the laboratory of clinical chemistry of the Maastricht University Medical Center.
- Caucasian ethnicity.
- BMI=18 - 30 kg/m2.
Exclusion
- History of gastro-intestinal disorders or abdominal surgery.
- History of alcohol abuse or current excessive alcohol consumption (\> 2 alcoholic beverages per day or \> 14 alcoholic beverages per week)40.
- Recent or chronic medications that may interact with ethanol metabolism or intestinal permeability i.e., NSAIDs, benzodiazepines and antidepressants.
- Smoking.
Key Trial Info
Start Date :
September 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 1 2012
Estimated Enrollment :
17 Patients enrolled
Trial Details
Trial ID
NCT00928733
Start Date
September 1 2009
End Date
January 1 2012
Last Update
November 13 2014
Active Locations (1)
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1
Maastricht University Medical Center
Maastricht, Limburg, Netherlands, 6202 AZ