Status:
COMPLETED
Comparison of Cardiac Computed Tomography and Vasodilator Stress Magnetic Resonance Imaging Perfusion in Patients With Prior Equivocal Stress Test for Detection of Coronary Artery Disease
Lead Sponsor:
National Heart, Lung, and Blood Institute (NHLBI)
Conditions:
Coronary Artery Disease
Eligibility:
All Genders
18-100 years
Brief Summary
Background: * Noninvasive cardiac stress testing is imperfect. Inconclusive test results generate further expensive testing. * In patients with known or suspected coronary artery disease, both comput...
Detailed Description
Noninvasive cardiac stress testing is imperfect. Inconclusive test results generate further expensive testing. We will do both cardiac computed tomography (CT) and stress cardiac magnetic resonance im...
Eligibility Criteria
Inclusion
- GENERAL INCLUSION CRITERIA:
- 18 years of age and older
- Prior equivocal stress study within the preceding 90 days
- Able to provide informed consent
- MEDICAL EXCLUSION CRITERIA:
- Decompensated heart failure (unable to lie flat during MRI or CT)
- Severe kidney disease (MDRD estimated Glomerular Filtration Rate less than 30mL/min/1.73m(2).
- Prior cardiac revascularization with coronary stent or bypass surgery
- Resting tachycardia (HR greater than l00 bpm)
- Pregnant women (when uncertain, subjects will undergo urine or blood testing)
- Lactating women (unless they are willing to discard breast milk for 24 hours after receiving gadolinium)
- Second (Type II) and third degree atrioventricular heart block
- Asthma or chronic pulmonary disease (emphysema) actively treated with bronchodilators or leukotriene antagonists
- MRI EXCLUSION CRITERIA:
- Cardiac pacemaker or implantable defibrillator
- Cerebral aneurysm clip
- Neural stimulator (e.g. TENS-Unit)
- Any type of ear implant
- Ocular foreign body (e.g. metal shavings)
- Any implanted device (e.g. insulin pump, drug infusion device)
- Metal shrapnel or bullet
Exclusion
Key Trial Info
Start Date :
July 1 2009
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
November 19 2020
Estimated Enrollment :
109 Patients enrolled
Trial Details
Trial ID
NCT00929227
Start Date
July 1 2009
End Date
November 19 2020
Last Update
December 3 2021
Active Locations (2)
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1
Suburban Hospital
Bethesda, Maryland, United States, 20814
2
National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States, 20892