Status:
UNKNOWN
Sleep-wake Changes of Luteinizing Hormone Frequency in Pubertal Girls With and Without High Testosterone
Lead Sponsor:
University of Virginia
Collaborating Sponsors:
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Conditions:
Hyperandrogenism
Eligibility:
FEMALE
8-15 years
Brief Summary
The purpose of this study is to determine whether sleep-wake changes of luteinizing hormone pulse frequency are different in early pubertal girls with high testosterone levels compared to early pubert...
Detailed Description
During early puberty, luteinizing hormone (LH) pulse frequency normally increases during sleep. In contrast, preliminary data suggest that obese girls (who have high testosterone levels in general) de...
Eligibility Criteria
Inclusion
- Early to midpubertal girls (late Tanner 1 \[i.e., estradiol \> 20 pg/ml\] to Tanner 3)
- Premenarcheal
- Approximate ages, 8-15 years
Exclusion
- BMI-for-age \< 5th percentile
- Inability to comprehend what will be done during the study or why it will be done
- Being a study of GnRH pulse regulation in adolescent girls with and without HA, boys are excluded
- Obesity associated with a diagnosed (genetic) syndrome (e.g., Prader-Willi syndrome, leptin deficiency), obesity related to medications (e.g., glucocorticoids), etc.
- Pregnancy or lactation
- Virilization
- Total testosterone \> 150 ng/dl (confirmed on repeat)
- DHEAS \> upper limit of age-appropriate normal range (confirmed on repeat) (mild elevations may be seen in adolescent HA, and elevations \< 1.5 times the age-appropriate upper limit of normal will be accepted in such girls)
- Follicular phase 17-hydroxyprogesterone \> 250 ng/dl (for girls \< 12 years old) or \> 300 ng/dl (for girls 12 and older) (confirmed on repeat), which suggests the possibility of congenital adrenal hyperplasia. NOTE: If an elevated follicular 17-hydroxyprogesterone is confirmed on repeat testing, an ACTH stimulated 17-hydroxyprogesterone \< 1000 ng/dl will be required for study participation
- History of premature adrenarche (i.e., appearance of pubic and/or axillary hair before age 8)
- A previous diagnosis of diabetes
- Fasting glucose ≥ 126 mg/dl, or a hemoglobin A1c \> 6.5% (confirmed on repeat)
- Abnormal TSH (confirmed on repeat) (subjects with adequately treated hypothyroidism, reflected by normal TSH values, will not be excluded)
- Abnormal prolactin (confirmed on repeat) (mild elevations may be seen in HA girls, and elevations \< 1.5 times the upper limit of normal will be accepted in this group)
- Evidence of Cushing's syndrome by history or physical exam (e.g., history of impaired growth in children, striae)
- Hematocrit \< 36% and hemoglobin \< 12 g/dl (confirmed on repeat)
- Significant history of cardiac or pulmonary dysfunction (e.g., known or suspected congestive heart failure; asthma requiring intermittent systemic corticosteroids; etc.)
- Persistent liver test abnormalities (confirmed on repeat), with the exception that mild bilirubin elevations will be accepted in the setting of known Gilbert's syndrome
- Persistently abnormal sodium, potassium, or elevated creatinine concentration (confirmed on repeat)
- Bicarbonate concentrations \< 20 or \> 30 (confirmed on repeat)
- No medications known to affect the reproductive system, glucose metabolism, lipid metabolism, or blood pressure can be taken in the 3 months prior to the first inpatient GCRC study (or in the 2 months prior to screening)
- Such medications include oral contraceptive pills, progestins, metformin, glucocorticoids, psychotropics, and sympathomimetics/stimulants (e.g., methylphenidate)
- Patients taking restricted medications will be excluded unless written permission (for the subjects to discontinue the medication) is received from the subject's physician
- Weight \< 22 kg is an absolute exclusion criterion (to ensure safe blood withdrawal)
Key Trial Info
Start Date :
October 1 2008
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
August 1 2023
Estimated Enrollment :
90 Patients enrolled
Trial Details
Trial ID
NCT00930007
Start Date
October 1 2008
End Date
August 1 2023
Last Update
May 18 2022
Active Locations (1)
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1
University of Virginia
Charlottesville, Virginia, United States, 22908