Status:
TERMINATED
CO2 Inhalation and Risk for Panic Disorder
Lead Sponsor:
National Institute of Mental Health (NIMH)
Conditions:
Panic Disorder
Eligibility:
All Genders
9-20 years
Brief Summary
Objective: To examine respiratory/physiological and subjective responding as well as genetic transmission among offspring of parents with a history of or current panic disorder (PD) diagnosis to dete...
Detailed Description
Objective: The objective of this study is to examine respiratory/physiological and subjective responding as well as genetic transmission among offspring of parents with a history of or current panic ...
Eligibility Criteria
Inclusion
- INCLUSION CRITERIA:
- Children age 9-18, and young adults 18-20 who have a parent with a past or current history of PD.
- EXCLUSION CRITERIA (ALL PARTICIPANTS):
- Serious, unstable illnesses including hepatic, renal, gastroenterologic, respiratory, cardiovascular, endocrinologic, neurologic, immunologic, or hematologic disease, one or more past seizures without a clear and resolved etiology,
- Subjects who are currently at high risk for homicide or suicide,
- Subjects with symptoms of psychosis
- Subjects with current DSM-IV substance abuse or dependence within the past year.
- Subjects with IQ\<70,
- ADDITIONAL EXCLUSION CRITERIA FOR CHILDREN:
- mania,
- pervasive developmental disorder,
- use of psychotropic medication,
- Child participants must be psychotropic free for at least 14 days prior to the CO(2) challenge session.
- For children taking fluoxetine, they must be free of this medication for at least 4 weeks.
- The proband parent must be a legal guardian of the child to qualify for the study.
- Offspring passing screening criteria will be scheduled for an intake to complete a clinical interview, questionnaires, and CO(2) challenge task with assessment of respiratory physiology.
Exclusion
Key Trial Info
Start Date :
June 26 2009
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
August 12 2019
Estimated Enrollment :
13 Patients enrolled
Trial Details
Trial ID
NCT00930657
Start Date
June 26 2009
End Date
August 12 2019
Last Update
August 14 2019
Active Locations (1)
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1
National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States, 20892