Status:
COMPLETED
Burn Healing and Analgesia With Propranolol
Lead Sponsor:
University of North Carolina, Chapel Hill
Conditions:
Burns
Pain
Eligibility:
All Genders
18-59 years
Phase:
PHASE2
Brief Summary
The purpose of this study is to investigate the ability of propranolol to decrease pain and improve recovery in burn patients with a common genotype.
Eligibility Criteria
Inclusion
- Thermal burn
- Greater than or equal to 18 years of age
- Less than 60 years of age
- Able to speak and read English
Exclusion
- Intubated
- Clinically unstable
- Other substantial comorbid injury (e.g. long bone fracture)
- Heart block greater than first degree (EKG)
- History of coronary artery disease
- History of congestive heart failure
- Asthma (within past 10 years, induced by a beta-blocker, or receiving current treatment)
- Pregnant
- Prisoner
- Psychotic, suicidal, or homicidal
- Diabetic
- Hepatic failure (acute or chronic)
- Renal failure (acute or chronic)
- History of hyperthyroidism unless taking synthroid or other thyroid hormone replacement
- Exceeds daily acceptable chronic opioid use prior to burn
- Interacting medication
- Received propranolol within the last 6 months
- Multiple severe allergic reactions
- On daily methylphenidate or similar stimulant medication
- Unwilling to use medically acceptable birth control (if childbearing potential)
- Breastfeeding
- Severe peripheral vascular disease or vasospastic disorder
- Bradycardia that in the opinion of the investigator would constitute too great a risk when considered in the context of the patient's medical comorbidities and health history
- Other criteria that in investigator's opinion makes participant poor candidate for the trial
- Cancer (except basal cell cancer)
Key Trial Info
Start Date :
July 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 1 2011
Estimated Enrollment :
45 Patients enrolled
Trial Details
Trial ID
NCT00934947
Start Date
July 1 2009
End Date
June 1 2011
Last Update
November 17 2017
Active Locations (4)
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1
Washington Hospital Center
Washington D.C., District of Columbia, United States, 20011
2
North Carolina Jaycee Burn Center
Chapel Hill, North Carolina, United States, 27514
3
Wake Forest University Baptist
Wake Forest, North Carolina, United States, 27587
4
Crozer Chester Medical Center
Upland, Pennsylvania, United States, 19102