Status:
UNKNOWN
Dopamine in Acute Decompensated Heart Failure (DAD-HF) Trial
Lead Sponsor:
Larissa University Hospital
Conditions:
Acute Heart Failure
Eligibility:
All Genders
18-90 years
Phase:
PHASE4
Brief Summary
The aim of this study is to compare the effects of high-dose furosemide versus low-dose furosemide combined with low-dose dopamine on diuresis, renal function, electrolyte balance, and 60-day post-dis...
Detailed Description
Worsening renal function (WRF) and hypokalemia related to diuretic use for acute decompensated heart failure (ADHF) are common and portend poor prognosis. Low dose dopamine infusion improves renal per...
Eligibility Criteria
Inclusion
- patients with New York Heart Association (NYHA) functional class IV heart failure according to the American Heart Association (AHA) classification, namely dyspnea on minimal exertion or rest dyspnea, orthopnea, and paroxysmal nocturnal dyspnea
- signs of congestion (third heart sound or pulmonary rales on physical examination)
- pulmonary congestion on chest x-ray
- serum B-type natriuretic peptide levels \> 400 pg/ml or NT-proBNP \> 1500 pg/ml
- echocardiographic documentation of systolic or diastolic dysfunction
- all candidate patients must be:
- Age \>18 years old
- on medical therapy with an ACE-inhibitor and/or a β-blocker
- experiencing an acute decompensation of known chronic HF
- Having baseline oxygen saturation \<90% on admission arterial blood gas
Exclusion
- the investigators will exclude patients with:
- acute de novo HF
- severe renal failure (serum creatinine \> 200 μmol/L or GFR \< 30 ml/min/1.73m2)
- admission systolic blood pressure \< 90 mm Hg
- severe valvular disease
- known adverse reactions to furosemide or dopamine
- HF secondary to congenital heart disease
- a scheduled procedure with a need for IV contrast dye
- a scheduled cardiac surgery within 6 months
Key Trial Info
Start Date :
January 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
July 1 2012
Estimated Enrollment :
300 Patients enrolled
Trial Details
Trial ID
NCT00937092
Start Date
January 1 2009
End Date
July 1 2012
Last Update
May 26 2010
Active Locations (2)
Enter a location and click search to find clinical trials sorted by distance.
1
Department of Cardiology, Larissa University Hospital
Larissa, Larissa, Greece, 411 10
2
Department of Cardiology, Volos General Hospital
Volos, Magnesia, Greece, 382 21