Status:
COMPLETED
Study of Bronchial Inflammation in Adolescent Smokers With and Without Obesity
Lead Sponsor:
Johann Wolfgang Goethe University Hospital
Conditions:
Obesity
Tobacco Smoking
Eligibility:
All Genders
14-22 years
Brief Summary
The investigators want to assess differences in lung function and bronchial inflammation of young smokers and non-smokers with (BMI \> 30) and without obesity (BMI \< 25)(4 patient groups). The aim of...
Detailed Description
Tobacco smoke is the crucial factor at the beginning and in the course of the bronchial inflammation leading to COPD. It has been shown that cigarette smoke in vitro leads to a MAP kinase and NF-κB-de...
Eligibility Criteria
Inclusion
- informed consent
- age between 14 and 22 years
- smokers CO ≥ 15 ppm
- non-smokers CO ≤ 6 ppm
Exclusion
- Asthma \> GINA I°
- others chronic diseases or infections (e.x. HIV, tuberculosis, malignancy)
- pregnancy
- therapy with systemic corticosteroids
- permanent treatment with inhaled corticosteroids
- documented alcohol, substance, and/or drug abuse
- incapability to perform all study procedure
Key Trial Info
Start Date :
October 1 2008
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
February 1 2010
Estimated Enrollment :
110 Patients enrolled
Trial Details
Trial ID
NCT00942019
Start Date
October 1 2008
End Date
February 1 2010
Last Update
July 5 2010
Active Locations (1)
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1
Children's Hospital, Goethe-University
Frankfurt am Main, Germany, 60596