Status:
COMPLETED
Early Family-Focused Treatment for Youth at Risk for Bipolar Disorder
Lead Sponsor:
University of California, Los Angeles
Collaborating Sponsors:
National Institute of Mental Health (NIMH)
Conditions:
Bipolar Disorder
Eligibility:
All Genders
9-17 years
Phase:
NA
Brief Summary
This study will test a family-based therapy aimed at preventing or reducing the symptoms of bipolar disorder in at-risk children.
Detailed Description
Early-onset bipolar disorder (BD) is a chronic, recurrent disorder that starts before age 18. In addition to the debilitating effects of BD, which include episodes of lethargic depression and exhausti...
Eligibility Criteria
Inclusion
- Has at least one biological parent or stepparent with whom the child or adolescent participant lives and who is willing to participate in family treatment
- Has a DSM-IV diagnosis of at least one of the following within the past 2 years : bipolar disorder not otherwise specified (BD-NOS), major depressive disorder (MDD), or cyclothymia
- If the main diagnosis is MDD, the depressive episode must have occurred within the past 2 years
- Has evidence of current significant affective symptoms, as determined by a score greater than 11 on the Young Mania Rating Scale within the last week or a score greater than 29 on the Child Depression Rating Scale-Revised within the last 2 weeks
- Not currently enrolled in family or marital therapy
- Has at least one biological parent or sibling with a verifiable diagnosis of bipolar disorder I or II
- Speaks English
Exclusion
- Fully diagnosable bipolar disorder I or II
- Diagnosis of autism or pervasive developmental disorder
- Evidence of mental retardation, as defined by an intelligence quotient (IQ) less than 70
- Presence of comorbid neurologic diseases such as seizure disorder
- Substance or alcohol abuse or dependence disorders in the 4 months prior to study recruitment
- Evidence of a life-threatening eating disorder or other medical disorder that requires emergency medical treatment
- Has previously been treated with family-focused therapy
- Evidence of current sexual or physical abuse or domestic abuse between the adult partners
Key Trial Info
Start Date :
April 1 2007
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
August 1 2011
Estimated Enrollment :
52 Patients enrolled
Trial Details
Trial ID
NCT00943085
Start Date
April 1 2007
End Date
August 1 2011
Last Update
March 26 2014
Active Locations (2)
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1
Stanford University School of Medicine, Lucile Packard Children's Hospital
Stanford, California, United States, 94304
2
University of Colorado, Boulder
Boulder, Colorado, United States, 80309-0345