Status:
UNKNOWN
Validation of New Tests for Gastrointestinal (GI) Permeability
Lead Sponsor:
Maastricht University Medical Center
Collaborating Sponsors:
Top Institute Food and Nutrition
Conditions:
Gastrointestinal Diseases
Eligibility:
All Genders
18-75 years
Phase:
EARLY_PHASE1
Brief Summary
Introduction: The primary function of the gastrointestinal (GI) wall is digestion and absorption of nutrients that are important for growth and development. The second important function of the GI wal...
Eligibility Criteria
Inclusion
- healthy controls, female/male, 18-75 years of age, OR:
- coeliac disease without taking medicine, female/male, 18-75 years of age
Exclusion
- cardiac and/or vascular disease
- chronic obstructive pulmonary disease (COPD)
- rheumatic arthritis (RA)
- Inflammatory bowel disease(IBD); Crohn's colitis or colitis ulcerosa
- Irritable bowel syndrome (IBS)
- Inflammatory systemic disease
- Obesity (Body Mass Index ≥ 30 kg/m²)
- Diabetes Mellitus
- Thyroid disease
- Kidney disease
- Cancer
- Smoking
- Substance abuse (alcohol, drug, cocain, opioids, and others)
- Use of drugs
- Operations to the GI system, apart from appendectomy
- Allergy to eggs or milk
- Hypersensitivity to any of the following: lactulose, l-rhamnose, sucrose, sucralose of erythritol
- Acute porphyria or phenylketonuria (PKU)
- Pregnancy
Key Trial Info
Start Date :
September 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
February 1 2012
Estimated Enrollment :
34 Patients enrolled
Trial Details
Trial ID
NCT00943345
Start Date
September 1 2009
End Date
February 1 2012
Last Update
November 8 2011
Active Locations (1)
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1
Maastricht University Medical Center
Maastricht, Zuid-Limburg, Netherlands