Status:
COMPLETED
Determinants of Oral Morphine Answer Among Obese Patients Before and After Gastric Bypass
Lead Sponsor:
Hopital Lariboisière
Conditions:
Obesity
Eligibility:
All Genders
18-60 years
Phase:
PHASE4
Brief Summary
The bariatric surgery is widely used to treat obesity. Roux-en-Y gastric bypass is one of the most frequently surgical methods performed and combines restrictive and malabsorptive procedures. Differen...
Eligibility Criteria
Inclusion
- Patients aged between 18 and 60 years old.
- Patients with morbid obesity (IMC \> 40 kg/m²) or severe obesity (IMC=35-40 kg/m²) with co morbidities (sleep apnea syndrome or hypertension or steatosis hepatitis) with a favourable decision of a multidisciplinary team for a gastric bypass.
- Patient agreeing to go 3 times for a one day hospitalisation in the URT of the Lariboisière Hospital for the morphine PK/PD.
- Patient with a previous medical examination.
- Patient giving its well-informed and free consent after information.
Exclusion
- diabetes
- concomitant sedative, antidepressive or analgesic treatments or drugs unadvised with morphine
- untreated sleep apnea syndrom, hypoxia (PaO2\<70mmHg) or hypercapnia (PaCO2\>45mmHg), anaemia \<10g/dL, ASAT or ALAT\>3N
Key Trial Info
Start Date :
April 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 1 2010
Estimated Enrollment :
31 Patients enrolled
Trial Details
Trial ID
NCT00943969
Start Date
April 1 2009
End Date
January 1 2010
Last Update
December 16 2015
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Unit of Therapeutic Research, Department of Internal Medicine, Lariboisière Hospital
Paris, France, 75475