Status:
COMPLETED
Misoprostol for Second Trimester Termination of Pregnancy
Lead Sponsor:
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Conditions:
Termination of Pregnancy Second Trimester
Eligibility:
FEMALE
16-60 years
Phase:
NA
Brief Summary
To compare the efficacy of two different dose regimens of misoprostol administered vaginally in combination with mifepristone in second trimester termination of (non)viable pregnancy.
Detailed Description
The study was designed as a prospective double blinded randomised controlled trial, comparing 200µg to 400 µg misoprostol given vaginally at four hour intervals, starting 36-48 hours after the oral ad...
Eligibility Criteria
Inclusion
- Women with a gestational age between 14 to 24 weeks, confirmed by ultrasound, requesting termination of pregnancy
Exclusion
- No informed consent
- Mifepristone allergy
- Chronic adrenal gland failure
- Kidney failure
- Liver failure
- Chronic use of corticosteroids
- COPD not responsive to treatment
- Cardiovascular disease
- Glaucoma
Key Trial Info
Start Date :
October 1 2000
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 1 2005
Estimated Enrollment :
176 Patients enrolled
Trial Details
Trial ID
NCT00945997
Start Date
October 1 2000
End Date
March 1 2005
Last Update
July 24 2009
Active Locations (1)
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1
Academic Medical Center
Amsterdam, Netherlands, 1105 AZ