Status:
RECRUITING
Development of a Biomarker Panel for the Earlier Prediction of Acute Kidney Injury in Patients With Diabetes
Lead Sponsor:
Barts & The London NHS Trust
Conditions:
Diabetes Mellitus
Renal Impairment
Eligibility:
All Genders
18+ years
Brief Summary
Patients living with diabetes mellitus have double the risk of kidney failure compared to patients without diabetes following use of dye in many x-rays and procedures to diagnose and treat narrowing o...
Detailed Description
Diabetes mellitus is an important risk factor for the development of contrast induced nephropathy (CIN), acting as a 'risk multiplier', amplifying the risk of acute kidney injury in these patients. Th...
Eligibility Criteria
Inclusion
- Age \> 18 years, known diabetes mellitus or BM on arrival consistent with probable diagnosis of diabetes, eGFR \<60 ml/min
- Undergoing a PCI procedure
- Agrees to the additional collection of blood and urine samples as outlined above
- Agrees to access of their clinical records for the collection of relevant medical data
- No history or signs of drug abuse
- Able to understand and sign the written Informed Consent Form
- Able and willing to follow the Protocol requirements
Exclusion
- Cardiogenic shock
- Pregnancy
- Patient on renal replacement therapy (haemodialysis/CAPD/renal transplant)
- Known clinically significant infection such as HIV, Hepatitis or TB
- Any patient determined not able to make a reasoned, informed consent prior to the planned interventional procedure
Key Trial Info
Start Date :
June 24 2009
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 31 2025
Estimated Enrollment :
250 Patients enrolled
Trial Details
Trial ID
NCT00948116
Start Date
June 24 2009
End Date
December 31 2025
Last Update
December 10 2024
Active Locations (1)
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1
The London Chest Hospital
London, United Kingdom, E2 9JX