Status:
UNKNOWN
Citrate Pharmacokinetics and Regional Citrate Anticoagulation in CRRT
Lead Sponsor:
Huashan Hospital
Collaborating Sponsors:
Shanghai Scientific and technology committe
Conditions:
Acute Kidney Failure With or Without:
MODS
Eligibility:
All Genders
18-80 years
Brief Summary
1. To compare the differences of citrate pharmacokinetics in healthy individuals and critically ill patients as well as the influential factors. 2. To validate a pharmacokinetic model which has been e...
Eligibility Criteria
Inclusion
- healthy individuals, none-pregnant
- diagnosed with acute renal failure according to RIFLE criteria
- ARF with hepatic insufficiency
- ARF with MODS or sepsis
- within informed consent
Exclusion
- used drugs with citrate within one week
- infused with blood,plasma or platelet or undergone plasma exchange therapy within 48 hours
- serious alkalosis with PH\>7.55
- serious lactic acidosis
- not in resuscitation state
Key Trial Info
Start Date :
March 1 2009
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
September 1 2011
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT00948558
Start Date
March 1 2009
End Date
September 1 2011
Last Update
August 6 2009
Active Locations (1)
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1
Huashan hospital
Shanghai, China, 200040