Status:
COMPLETED
Potassium Intake in Patients With Chronic Kidney Disease
Lead Sponsor:
Johns Hopkins University
Collaborating Sponsors:
American Heart Association
Conditions:
Chronic Kidney Disease
Hypertension
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Chronic kidney disease is associated with high blood pressure, heart disease, and strokes. Potassium lowers blood pressure and may help prevent heart disease and strokes in the general population, but...
Detailed Description
In individuals without chronic kidney disease (CKD), potassium (K) lowers blood pressure (BP) and may help prevent cardiovascular disease (CVD) and stroke. In animal models, K prevented kidney injury ...
Eligibility Criteria
Inclusion
- Stage 3 chronic kidney disease (estimated glomerular filtration rate 30-59 mL/min/1.73 m2 by the 4-variable Modification of Diet in Renal Disease (MDRD) Study Equation
- Systolic blood pressure 120-159 mm Hg and diastolic blood pressure \< 100 mm Hg
- Willingness to follow strict dietary rules for 9 weeks and to come to the clinical research unit at least 3 weekdays per week for one meal during the two study periods
Exclusion
- Baseline serum potassium of at least 5.5 mEq/L
- Baseline serum potassium of less than 3.5 mEq/L
- Insulin-requiring or uncontrolled (HbA1C \> 9 g/dL) diabetes mellitus
- Use of potassium supplements
- Use of digoxin
- Chronic disease(s) that may interfere with trial participation
- Pregnancy or lactation
- \> 14 alcoholic drinks/week
- Major food allergies or intolerances
Key Trial Info
Start Date :
July 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 1 2011
Estimated Enrollment :
29 Patients enrolled
Trial Details
Trial ID
NCT00949585
Start Date
July 1 2009
End Date
June 1 2011
Last Update
September 19 2012
Active Locations (1)
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1
Johns Hopkins University Pro Health Clinical Research Facility
Baltimore, Maryland, United States, 21207