Status:
UNKNOWN
Prevention of Contrast-Induced Nephropathy in Diabetic Patients With Undergoing Coronary Angiography
Lead Sponsor:
CardioVascular Research Foundation, Korea
Conditions:
Contrast Induced Nephropathy
Eligibility:
All Genders
18+ years
Phase:
PHASE4
Brief Summary
The aim of this study is to determine whether sodium bicarbonate is superior to sodium chloride in preventing contrast induced nephropathy in diabetic patients undergoing coronary angiography or inter...
Detailed Description
Contrast induced nephropathy (CIN) is a common cause of renal failure associated with prolonged hospitalization, significant morbidity or mortality, and cost. CIN has been reported to account for 10% ...
Eligibility Criteria
Inclusion
- age\>18 years, no upper limits
- diabetes treated with insulin or oral hypoglycemic agents
- serum creatinine \>=1.1 and
- resting estimated glomerular filtration rate \<60ml/min/1.73 square meter
Exclusion
- serum creatinine \>=8mg/dL
- resting estimated GFR \<15ml/min/1.73 square meter
- end stage renal disease on hemodialysis
- multiple myeloma
- uncontrolled hypertension (systolic BP \>160mmHg or diastolic BP\>100mmHg)
- acute myocardial infarction
- emergent coronary angioplasty or angiography
- recent use of contrast within 2 days
- allergic reaction to contrast
- pregnancy
- allergic to following medication : theophylline, dopamine, mannitol, fenoldopam, N-acetylcysteine
Key Trial Info
Start Date :
February 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
January 1 2010
Estimated Enrollment :
368 Patients enrolled
Trial Details
Trial ID
NCT00950079
Start Date
February 1 2008
End Date
January 1 2010
Last Update
July 31 2009
Active Locations (9)
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1
Soonchunhyang University Bucheon Hospital
Bucheon-si, South Korea
2
Busan Saint Mary Hospital
Busan, South Korea
3
Soonchunhyang University Hospital, Cheonan
Cheonan, South Korea
4
Kangwon National University Hospital
Chuncheon, South Korea