Status:
COMPLETED
CYTRAM (Cytochrome P450, Tramadol)
Lead Sponsor:
University Hospital, Caen
Conditions:
Post-operative Patients Treated by Tramadol
Eligibility:
All Genders
18+ years
Brief Summary
Many methods to detect CYP2D6 poor metabolizers have been validated. Some of them are based on phenotyping (metabolism of dextromethorphan or debrisoquine) and some others on genotyping. Up to now, CY...
Eligibility Criteria
Inclusion
- age \> 18 years, post-operative patient treated with intravenous tramadol
- Caucasian origin
- take of blood at H24 and H48 in the post-operative monitoring
Exclusion
- patient having already been included in the study
- patient taking opioid drugs before surgery
- patient taking one or more drugs inhibiting the CYP2D6 before or during surgery
- pregnancy or breast feeding patients having one or more contraindications for taking tramadol in post-operative analgesia
- hepatocellular incapacity (TP \< 70%)
Key Trial Info
Start Date :
April 1 2010
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
June 1 2011
Estimated Enrollment :
301 Patients enrolled
Trial Details
Trial ID
NCT00952159
Start Date
April 1 2010
End Date
June 1 2011
Last Update
July 4 2011
Active Locations (4)
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1
Private Clinic Saint-Martin
Caen, France, 14000
2
Caen University Hospital
Caen, France, 14033
3
Créteil University Hospital
Créteil, France
4
Rouen University Hospital
Rouen, France, 76000