Status:
WITHDRAWN
Antibiotics in Chronic Obstructive Pulmonary Disease (COPD)
Lead Sponsor:
Odense University Hospital
Collaborating Sponsors:
Kolding Sygehus
Svendborg Hospital
Conditions:
Pulmonary Disease, Chronic Obstructive
Eligibility:
All Genders
50+ years
Phase:
PHASE4
Brief Summary
It is not clear whether antibiotic therapy is needed in patients with mild to moderate exacerbation of chronic obstructive lung disease. The aim of the study is to compare the effect of 1 day of treat...
Eligibility Criteria
Inclusion
- Age above 50 years
- History of smoking
- History of COPD
- Antibiotics for 24 hours
- At least 2 of the following: dyspnoea, coughing with sputum, and sputum with purulence
- Informed consent
Exclusion
- Pneumonia
- Antibiotics for more than 36 hours
- Antibiotics for other infection
- Prednisolone, more than 0.5 mg/kg body weight/24 hours for more than 3 days
- Malignancy
- Other pulmonary disease
- Immune deficiency
- Not able to tolerate doxycycline
- Severe heart, liver or kidney disease
- Epilepsia
- Not stable 24 hours after hospital admission
- Need for assisted ventilation
Key Trial Info
Start Date :
October 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2010
Estimated Enrollment :
140 Patients enrolled
Trial Details
Trial ID
NCT00952861
Start Date
October 1 2009
End Date
December 1 2010
Last Update
August 11 2010
Active Locations (1)
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1
Odense University Hospital
Odense, Denmark, 5000