Status:
COMPLETED
The Effects of Glucocorticoids on Mortality and Renal Function in Patients With Acute Decompensated Heart Failure
Lead Sponsor:
Hebei Medical University
Conditions:
Heart Failure
Eligibility:
All Genders
18+ years
Phase:
PHASE2
PHASE3
Brief Summary
Evidence showed that glucocorticoids could induce potent diuretic actions and improve renal functions in patients with decompensated congestive heart failure. Thus we design this study to determine th...
Detailed Description
Newly emerging clinical evidence showed glucocorticoids, when added to best conventional therapy, could produce potent diuretic effects, and improve renal functions in patients with decompensated cong...
Eligibility Criteria
Inclusion
- Patients with dyspnea at rest due to acutely decompensated CHF requiring hospitalization and intravenous therapy. The cardiac etiology for acutely decompensated CHF was established by echocardiogram and/or a chest x-ray film and 2 of the following:
- \>2-pillow orthopnea before study entry
- Jugular venous distention and/or abdominal discomfort due to mesenteric congestion.
- Patients may have had acute decompensation of chronic heart failure, gradual worsening of chronic heart failure, or new onset of acutely decompensated CHF. Patients who were receiving intravenous therapy i.e. Inotropic and/or vasodilator but who otherwise met entry criteria were also permitted into the study. Patients with signs of cardiac shock were also permitted into the study.
Exclusion
- Patient refusal
- Any signs of infection
- any condition that would contraindicate a glucocorticoids use
- Poor controlled hypertension
- Poor controlled diabetes mellitus
- Active myocarditis
- Malignancy or other terminal illness
Key Trial Info
Start Date :
January 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 1 2012
Estimated Enrollment :
102 Patients enrolled
Trial Details
Trial ID
NCT00953303
Start Date
January 1 2009
End Date
January 1 2012
Last Update
February 22 2012
Active Locations (1)
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1
The First Hospital of Hebei Medical University
Shijiazhuang, Hebei, China, 050031