Status:
COMPLETED
The Prevalence of Thiamin Deficiency in Ambulatory Patients With Heart Failure
Lead Sponsor:
Unity Health Toronto
Collaborating Sponsors:
Canadian Foundation for Dietetic Research (CFDR)
Conditions:
Heart Failure
Eligibility:
All Genders
18+ years
Brief Summary
Patients with heart failure are at an increased risk for thiamin deficiency (TD), for many reasons such as malnutrition and the use of diuretic drugs. Thiamin is a B vitamin that plays an important ro...
Detailed Description
Thiamin is a water-soluble B-complex vitamin which is supplied primarily from cereals and enriched grains in the ordinary diet. The majority of absorbed thiamin combines with ATP in the body to form t...
Eligibility Criteria
Inclusion
- Patients with the primary diagnosis of ischemic, dilated, idiopathic or valvular HF characterized by an ejection fraction of \< 45% (echocardiography or radionuclide scan)
- Patients with NYHA class I-IV symptoms
Exclusion
- Patients who are unable or unwilling to provide informed consent
- Patients with any concurrent condition which would result in TD, namely, gastrointestinal disorders (Crohn's disease, ulcerative colitis), liver disease, prolonged diarrhoeal disease, dialysis, prolonged fever, infection or renal failure
- Patients who are rapidly deteriorating, who are not on a stable medication regimen (≥ 2 months) or have been hospitalized for acute decompensated HF in the last 2 months
- Patients who are on experimental medications
- Patients who consume excessive alcohol (\> 3 drinks per day), have a documented history of alcoholism or have documented alcoholic cardiomyopathy
- Patients who are pregnant
Key Trial Info
Start Date :
May 1 2009
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
December 1 2012
Estimated Enrollment :
110 Patients enrolled
Trial Details
Trial ID
NCT00953823
Start Date
May 1 2009
End Date
December 1 2012
Last Update
December 24 2012
Active Locations (1)
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1
St. Michael's Hospital
Toronto, Ontario, Canada