Status:
COMPLETED
Nicotine Patch, Blood Flow and Oxidative Stress Study
Lead Sponsor:
University of Pennsylvania
Collaborating Sponsors:
National Institutes of Health (NIH)
Conditions:
Healthy
Eligibility:
All Genders
18-45 years
Phase:
NA
Brief Summary
This study will address the hypothesis that nicotine, like cigarette smoking acting as a pro-oxidant may have adverse effects on arterial function.
Detailed Description
Smoking causes \>400,000 deaths from cardiovascular disease (CVD) per year. The molecular basis of smoking induced tissue injury remains unclear but considerable evidence supports a role for oxidant s...
Eligibility Criteria
Inclusion
- Healthy individuals
- Nonsmokers who have never smoked
- Normal medical history
- Normal physical examination
- Normal laboratory data
- Negative urinary pregnancy test for females
Exclusion
- Previous CVD
- Chronic medication use
- History alcoholism
- History of smoking
- Current pregnancy
- Subjects, who have less than or equal to 60% platelet aggregation in response to arachidonic acid will also be excluded.
Key Trial Info
Start Date :
October 1 2002
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2006
Estimated Enrollment :
55 Patients enrolled
Trial Details
Trial ID
NCT00954096
Start Date
October 1 2002
End Date
December 1 2006
Last Update
October 27 2009
Active Locations (1)
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1
University of Pennsylvania
Philadelphia, Pennsylvania, United States, 19104