Status:
COMPLETED
Phase Ib Study of Erlotinib Prior to Surgery in Patients With Head and Neck Cancer
Lead Sponsor:
M.D. Anderson Cancer Center
Collaborating Sponsors:
National Cancer Institute (NCI)
Conditions:
Recurrent Head and Neck Carcinoma
Recurrent Salivary Gland Carcinoma
Eligibility:
All Genders
18+ years
Phase:
PHASE1
Brief Summary
This randomized phase Ib trial studies standard-dose or high-dose erlotinib hydrochloride before surgery in treating patients with head and neck cancer. Erlotinib hydrochloride may stop the growth of ...
Detailed Description
PRIMARY OBJECTIVES: I. To determine the effects of erlotinib (erlotinib hydrochloride) 150 mg/day (standard dose) and 200 mg/day or 300 mg/day (high-dose) on the phosphorylation of AKT protein downst...
Eligibility Criteria
Inclusion
- Patients with histologically confirmed cancer of the head and neck. Patients with salivary gland tumors and squamous cell carcinomas of the skin are also eligible. (Note: Any patient with a diagnosis of aggressive squamous cell carcinoma of the skin and determined to be surgically resectable will be considered for eligibility. These patients are typically seen in the Head \& Neck surgery clinic and decisions for study consideration will be based on consultations with the department of Head \& Neck surgery.)
- The patient must have biopsy-accessible disease.
- Patients must be surgical candidates (either definitive or palliative setting).
- Patients may have received prior therapy including cytotoxic chemotherapy (e.g. platinum drugs and taxanes) and radiation therapy.
- Patients must have a performance score (ECOG) of 0-2.
- Patients should have adequate bone marrow function, as defined by peripheral granulocyte count of \>/= 1,000/mm³, and a platelet count of \>/= 50,000/mm³.Patients must have adequate liver function with a bilirubin \</= 1.5 times the upper limit of normal (ULN). Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) must be \</= 2 x the ULN and alkaline phosphatase must be \</= 2 x ULN.
- Patients should have adequate renal function (serum creatinine \</= 1.5 x ULN).
- Age \>/= 18 years
- Ability to understand and the willingness to sign a written informed consent document indicating that they are aware of the investigational nature of the study, in keeping with institutional policy
- Women of childbearing potential must agree to use adequate contraception (hormonal or barrier method of birth control; abstinence) prior to study entry and for the duration of study participation. Childbearing potential will be defined as women who have had menses within the past 12 months,who have not had tubal ligation or bilateral oophorectomy. Should a woman become pregnant or suspect that she is pregnant while participating in this study,she should inform her treating physician immediately.The patient,if a man,agrees to use effective contraception or abstinence.
Exclusion
- Patients with prior exposure to small molecule tyrosine kinase inhibitors or EGFR-targeted antibodies within the past 6 months.
- Patients for whom, in the opinion of the treating surgeon, the administration of erlotinib would cause a deleterious delay in surgical treatment.
- Patients with uncompensated congestive cardiac failure.
- Patients with an organ allograft.
- Patients with a serious concurrent infection or illness including, but not limited to, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness that could limit compliance with study requirements.
- Female patients who are pregnant or breastfeeding
- Patients currently on chemotherapy, immunotherapy, or therapy with monoclonal antibodies or other investigational agents with anti-tumor activity
Key Trial Info
Start Date :
August 5 2009
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
April 30 2025
Estimated Enrollment :
48 Patients enrolled
Trial Details
Trial ID
NCT00954226
Start Date
August 5 2009
End Date
April 30 2025
Last Update
September 5 2025
Active Locations (1)
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1
M D Anderson Cancer Center
Houston, Texas, United States, 77030