Status:
COMPLETED
The Effect of Asthma on Systemic Inflammation, Oxidative Stress and Cardiovascular Morbidity
Lead Sponsor:
The University of Hong Kong
Conditions:
Asthma
Eligibility:
All Genders
35-74 years
Brief Summary
Asthma is a chronic airway inflammation which involves the interplay of different types of inflammatory cells and cytokines in the airway. The presence of systemic inflammation and oxidative stress in...
Detailed Description
Asthma is a chronic inflammatory airway disorder, associated with airflow obstruction and bronchial hyper-responsiveness, which affects about 10% of population in Hong Kong. It has been a major respir...
Eligibility Criteria
Inclusion
- Asthma patients with stable persistent asthma
- Current inhaled corticosteroid users
Exclusion
- On maintenance oral steroid
- Systemic steroid use in recent 1 month
- Asthma exacerbation (GINA criteria) in recent 1 month (ie daytime or nocturnal symptoms increment, detectable wheezing on physical examination, drop in peak flow rate, drop in spirometry indexes, increase in asthma medication, emergency medical attendance for asthma, days off work for asthma etc)
- Inhaled corticosteroid use for \< 6 months
- Pregnancy
Key Trial Info
Start Date :
September 1 2008
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
July 1 2009
Estimated Enrollment :
748 Patients enrolled
Trial Details
Trial ID
NCT00957281
Start Date
September 1 2008
End Date
July 1 2009
Last Update
August 12 2009
Active Locations (4)
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1
Kowloon Hospital
Hong Kong, Hong Kong
2
Kwong Wah Hospital
Hong Kong, Hong Kong
3
Queen Elizabeth Hospital
Hong Kong, Hong Kong
4
Queen Mary Hospital
Hong Kong, Hong Kong