Status:
COMPLETED
To Assess Neuroinflammation and Neurocognitive Function in Patients With Acute Hepatitis C and Chronic HIV Co-Infection
Lead Sponsor:
Imperial College London
Conditions:
Acute Hepatitis C
HIV
Eligibility:
MALE
25+ years
Phase:
NA
Brief Summary
This study plans to evaluate what happens to the brain in patients with HIV and early hepatitis C. The investigators will be comparing 3 groups of individuals: * Group 1: Individuals with HIV infecti...
Detailed Description
Subtle changes to the brain, which doctors find difficult to detect through conversation or examination, may occur in patients with HIV and/or hepatitis C infection. It is not currently known whether ...
Eligibility Criteria
Inclusion
- HIV-1 antibody positive for at least 12 months
- Acute HCV (Blood HCV PCR positive with negative PCR within past 8 months)
- HCV genotype 1
- Ability to give informed consent
- Aged \> 25 years
- Male
- Abbreviated Mental Test Score of at least 8/10
Exclusion
- Evidence of established cirrhosis or encephalopathy
- Commencing or any change to HIV medications within 12 weeks
- Active opportunistic infection
- Taking anti-depressants or any psychoactive medications within past 4 weeks
- Use of benzodiazepines within past 4 weeks
- Recent significant head injury
- Established dementia
- Alcohol dependence or recreational drug misuse
- Untreated early syphilis
- Hepatitis B infection (HBsAg positive)
- Pregnancy
- Unable to give informed consent
- Any contraindication to MR scanning
Key Trial Info
Start Date :
June 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 1 2011
Estimated Enrollment :
81 Patients enrolled
Trial Details
Trial ID
NCT00959166
Start Date
June 1 2009
End Date
September 1 2011
Last Update
October 22 2019
Active Locations (1)
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1
St Mary's Hospital
London, United Kingdom, W2 1NY