Status:
COMPLETED
The Effect of Long Term Inhaled Corticosteroids on the Risk of Cardiovascular Morbidities
Lead Sponsor:
The University of Hong Kong
Conditions:
Asthma
Eligibility:
All Genders
35-74 years
Brief Summary
Cardiovascular disease is a major cause of morbidity and mortality worldwide. It is the second leading cause of death in Hong Kong. The disease burden is huge and effective control measures should tar...
Detailed Description
Globally, cardiovascular disease is a major cause of mortality and morbidity. In the past 2 decades in Hong Kong, it has been the second leading cause of death, with death rate reaching 50/100,000 pop...
Eligibility Criteria
Inclusion
- Adult Chinese asthma patients
- Stable persistent asthma who are current inhaled corticosteroid users OR
- Healthy controls will be non inhaled corticosteroid users matched for age, gender and BMI from the Hong Kong Cardiovascular Risk Factor Prevalence Study II (CRISPSII) carried out on a random population sample in Hong Kong
Exclusion
- On maintenance oral steroid
- Systemic steroid use in recent 6 months
- Asthma exacerbation (GINA criteria) in recent 1 month (ie daytime or nocturnal symptoms increment, detectable wheezing on physical examination, drop in peak flow rate, drop in spirometry indexes, increase in asthma medication, emergency medical attendance for asthma, days off work for asthma etc)
- Inhaled corticosteroid use for \< 6 months
- Pregnancy
Key Trial Info
Start Date :
January 1 2009
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
July 1 2009
Estimated Enrollment :
1394 Patients enrolled
Trial Details
Trial ID
NCT00959257
Start Date
January 1 2009
End Date
July 1 2009
Last Update
August 14 2009
Active Locations (4)
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1
Kowloon Hospital
Hong Kong, Hong Kong
2
Kwong Wah Hospital
Hong Kong, Hong Kong
3
Queen Elizabeth Hospital
Hong Kong, Hong Kong
4
Queen Mary Hospital
Hong Kong, Hong Kong