Status:
COMPLETED
A/H1N1 Immunogenicity and Safety in Adults
Lead Sponsor:
Alachua Government Services, Inc.
Conditions:
Influenza
Pandemic Influenza
Eligibility:
All Genders
18+ years
Phase:
PHASE1
PHASE2
Brief Summary
The purpose of the study is to obtain immunogenicity and safety data at different dose levels of an investigational H1N1 pandemic influenza vaccine in healthy adults 18 years of age and older.
Eligibility Criteria
Inclusion
- Subject is 18 to 59 years old (age stratum A) or 60 years of age or older (age stratum B) at the time of screening
- Subject has an understanding of the study, agrees to its provisions, and gives written informed consent prior to study entry
- Subject is generally healthy, as determined by the investigator's clinical judgment through collection of medical history and the performance of a physical examination
- Subject is physically and mentally capable of participating in the study and willing to adhere to study procedures to include completion of all elements of the study diary
- If female of childbearing potential, subject has a negative urine pregnancy test result within 24 hours prior to the scheduled first vaccination and agrees to employ adequate birth control measures for the duration of the study
Exclusion
- Subject has participated in another clinical study involving an investigational drug, biological product or device within 30 days prior to study enrollment or is scheduled to participate in another clinical study involving an investigational drug, biological or device during the course of this study
- Subject has a history of exposure to A/H1N1/California/07/2009 virus or a history of vaccination with A/H1N1/California/07/2009 antigen or a closely related influenza virus antigen
- Subject has inherited or acquired immune deficiency
- Subject currently has or has a recent history of significant neurological, cardiovascular or pulmonary (including asthma), hepatic, metabolic, rheumatic, autoimmune, hematological or renal disorder
Key Trial Info
Start Date :
August 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
April 1 2010
Estimated Enrollment :
408 Patients enrolled
Trial Details
Trial ID
NCT00959465
Start Date
August 1 2009
End Date
April 1 2010
Last Update
October 9 2015
Active Locations (5)
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1
Sanatorium Leech
Graz, Austria, 8010
2
ClinPharm International GmbH
Vienna, Austria, 1090
3
Medical University of Vienna, Institute for Specific Prophylaxis and Tropical Medicine
Vienna, Austria, 1090
4
University Hospital, Department of Clinical Pharmacology
Vienna, Austria, 1090