Status:
COMPLETED
Exercise Intolerance in Elderly Patients With Diastolic Heart Failure
Lead Sponsor:
Wake Forest University
Collaborating Sponsors:
National Institute on Aging (NIA)
Conditions:
Heart Failure, Diastolic
Obesity
Eligibility:
All Genders
60+ years
Phase:
NA
Brief Summary
The purpose of this study is to examine the effects of weight loss via hypocaloric diet, aerobic exercise training, combined hypocaloric diet and exercise training, and attention control in patients w...
Detailed Description
Heart failure with a normal ejection fraction (HFNEF, previously termed diastolic heart failure), accounts for the majority of heart failure cases in the population \> 65 years old and has been recogn...
Eligibility Criteria
Inclusion
- Heart failure clinical score greater than or equal to 3
- Age 60 and over
- Normal ejection fraction greater than or equal to 50%
- BMI greater than or equal to 30
Exclusion
- Valvular heart disease
- Significant change in cardiac medication \<4 weeks
- Uncontrolled hypertension
- Recent or debilitating stroke
- Cancer or other noncardiovascular conditions with life expectancy less than 2 years
- Significant Anemia
- Renal insufficiency (creatinine \>2.5mg/dl)
- Psychiatric disease- uncontrolled major psychoses, depressions, dementia, or personality disorder
- Plans to leave area within 6 months
- Refuses informed consent
- Failure to pass screening test:pulmonary function, echocardiogram,or exercise
Key Trial Info
Start Date :
February 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 1 2013
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT00959660
Start Date
February 1 2009
End Date
August 1 2013
Last Update
February 15 2019
Active Locations (1)
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1
Wake Forest University Health Sciences
Winston-Salem, North Carolina, United States, 271757