Status:
COMPLETED
Safety Study of Increasing Doses of Combretasatin A1 Diphosphate (OXi4503) as Monotherapy in Subjects With Hepatic Tumor Burden
Lead Sponsor:
Mateon Therapeutics
Conditions:
Neoplasm Metastasis
Eligibility:
All Genders
18+ years
Phase:
PHASE1
Brief Summary
The purpose of this study is to determine the safety and tolerability of OXi4503 in subjects with relapsed or refractory carcinomas with hepatic tumor burden.
Eligibility Criteria
Inclusion
- Histologically or cytologically confirmed carcinoma. Tumor must be relapsed or refractory to standard therapies, or have no acceptable standard therapy.
- Measurable disease by RECIST criteria.
- Subjects must be at least 28 days from other investigational therapy and at least 2 weeks after chemotherapy or radiation therapy.
- Age 18 years or older.
- Eastern Cooperative Oncology Group (ECOG) Performance Score of less than 1.
- Life expectancy of greater than 12 weeks.
- Hemoglobin greater than 10 g/dL.
- Adequate hepatic function.
- Adequate renal function.
- Adequate bone marrow reserve.
- Able to maintain potassium, calcium and magnesium levels within normal ranges.
- Must be able to provide written informed consent.
- All women of childbearing potential (WOCBP) must have a negative serum pregnancy test.
- WOCBP and fertile men and their partners must agree to use an effective form of contraception during the study and for 90 days after the last dose of study medication.
Exclusion
- Uncontrolled CNS metastases.
- No other active malignancies.
- Poorly controlled hypertension.
- Recent history of serious cardiovascular conditions.
- Recent history of CVA, TIA, or intermittent claudication.
- Current anticoagulation therapy.
- History of cardiac arrhythmias.
- Abnormal ECG findings.
- Subjects who require concomitant medications which cause QTc prolongation.
- Major surgery within 30 days of treatment, or minor surgery within 7 days of treatment.
- Uncontrolled, clinically significant active infection.
- Subjects who are pregnant or lactating.
- Subjects with any other intercurrent medical condition.
- Subjects with a history of solid organ transplant or bone marrow transplant.
Key Trial Info
Start Date :
July 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
October 1 2010
Estimated Enrollment :
16 Patients enrolled
Trial Details
Trial ID
NCT00960557
Start Date
July 1 2009
End Date
October 1 2010
Last Update
August 23 2011
Active Locations (4)
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1
OXiGENE Investigational Site
Westmead, New South Wales, Australia, 2145
2
OXiGENE Investigational Site
South Brisbane, Queensland, Australia, 4101
3
OXiGENE Investigational Site
Adelaide, South Australia, Australia, 5000
4
OXiGENE Investigational Site
Bentleigh, Victoria, Australia, 3165