Status:
WITHDRAWN
Work of Breathing and Mechanical Ventilation in Acute Lung Injury
Lead Sponsor:
University of California, San Francisco
Conditions:
Acute Lung Injury
Eligibility:
All Genders
18-85 years
Phase:
NA
Brief Summary
The primary goal of this study is to measure changes in biological markers of inflammation in critically-ill patients with acute lung injury (ALI) or acute respiratory distress syndrome (ARDS) while t...
Detailed Description
Ventilator-induced lung injury contributes to the progression of ALI/ARDS,1 and is thought to occur partly from the unequal distribution of a super-normal tidal volume to normal areas of the lung.2 Al...
Eligibility Criteria
Inclusion
- Both medical and surgical patients undergoing mechanical ventilatory support who meet criteria for Acute Lung Injury (ALI) or Acute Respiratory Distress Syndrome (ARDS) as defined by the European-American Consensus Conference,
- Mechanical ventilation via an endotracheal or tracheotomy tube,
- PaO2/FiO2 \< 300 mmHg with bilateral infiltrates on chest radiogram,
- Clinical management with lung protective ventilation (Tidal volume \< 8 mL/kg).
Exclusion
- Patients receiving "comfort care",
- High cervical spinal cord injury or other neuromuscular disease,
- Prisoners,
- Pregnancy,
- Less than 18 years of age,
- Facial fractures and coagulopathies,
- Patients placed on psychiatric hold.
Key Trial Info
Start Date :
September 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 1 2013
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT00961168
Start Date
September 1 2009
End Date
September 1 2013
Last Update
March 5 2015
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