Status:
COMPLETED
Photobiomodulation to Alter Cerebral Blood Flow and to Affect the Emotional Status of Patients With Major Depression
Lead Sponsor:
Massachusetts General Hospital
Conditions:
Major Depression
Anxiety Disorder
Eligibility:
All Genders
18-60 years
Phase:
PHASE1
Brief Summary
A pilot study to evaluate the ability of photobiomodulation to alter cerebral blood flow in the frontal poles and to affect the emotional status of patients with major depression.
Detailed Description
We wish to study whether photobiomodulation (PBM) with near infrared (NIR) light emitting diodes (LED), a non-ionizing phototherapy, in patients with major depression, can acutely alter frontal brain ...
Eligibility Criteria
Inclusion
- All patients must be right handed, between the ages of 18 and 60, and meet criterion for depression on a Structured Clinical Diagnostic Interview
- Enrollment will be made without regard to gender or ethnicity
- Patients who are receiving treatment for depression, either psychological or pharmacological, may continue their treatment during the time of the study, but will be asked to try not to alter their treatment from one month prior to the onset of the experiment until its conclusion. If they must alter their treatment, the patient will continue in the study for observation, but will be excluded from any follow-up statistical comparisons
Exclusion
- Past history of psychotic disorder (including schizophrenia or schizoaffective disorder
- Bipolar disorder
- Obsessive compulsive disorder)
- Substance abuse disorder that has been active with the past 6 months,
- A history of violent behavior
- A history of a past suicide gesture or attempt
- A history of current suicidal ideation
- A history of a neurological condition (e.g. epilepsy, traumatic brain injury, stroke)
- Pregnancy
- Current acute or chronic medical condition requiring a medications that has psychological side-effects
- Any person whom we judge to have an impaired decision-making capacity
Key Trial Info
Start Date :
January 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 1 2009
Estimated Enrollment :
10 Patients enrolled
Trial Details
Trial ID
NCT00961454
Start Date
January 1 2009
End Date
June 1 2009
Last Update
August 19 2009
Active Locations (1)
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1
Wellman Center for Photomedicine, Massachusetts General Hospital
Boston, Massachusetts, United States, 02114