Status:
TERMINATED
Canadian Varicocelectomy Initiative (CVI): Effects on Male Fertility and Testicular Function of Varicocelectomy
Lead Sponsor:
Mount Sinai Hospital, Canada
Collaborating Sponsors:
McGill University
Dalhousie University
Conditions:
Male Infertility
Varicoceles
Eligibility:
MALE
20-65 years
Phase:
NA
Brief Summary
A varicocele is the presence of dilated testicular veins in the scrotum. Although it is generally agreed that a varicocele is the most common identifiable pathology in infertile men (detected in up to...
Detailed Description
INTRODUCTION: A varicocele is the most common detectable factor in infertile men (found in approximately 40% of men with infertility) and varicocelectomy is the most commonly performed surgery to tre...
Eligibility Criteria
Inclusion
- Minimum of one year of infertility
- Clinically detectable grade 2 or grade 3 varicocele
- A minimum of 2 abnormal semen analyses (defined as \< 20 million sperm/ml, and/or \< 30% progressive motility and/or normal sperm morphology \< 14% by Kruger Strict Morphology (WHO) within 6 months of entry into the study)
- Female partner \< 38 years of age
Exclusion
- Other medically correctable cause of infertility (e.g., prolactinoma, infection, exposure to marijuana)
- Severe oligospermia on 2 sperm analyses (defined as \< 5 million sperm/ml)
- Severe asthenospermia on 2 sperm analyses (\< 5% progressive motility)
- Prior varicocele repair
- Solitary testicle
- Significant female-factor infertility (tubal factor or anovulation only)
- Inability or unwillingness to comply with study protocol (including failure to submit 2 post-intervention semen samples)
Key Trial Info
Start Date :
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
Estimated Enrollment :
300 Patients enrolled
Trial Details
Trial ID
NCT00961558
Last Update
May 28 2012
Active Locations (4)
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1
Queen Elizabeth II Health Sciences Centre
Halifax, Nova Scotia, Canada, B3H 2A7
2
Mount Sinai Hospital
Toronto, Ontario, Canada, M5G 1X5
3
McGill University Health Centre; Royal Victoria Hospital
Montreal, Quebec, Canada, H3A 1A1
4
McGill University; St. Mary Hospital Centre
Montreal, Quebec, Canada, H3T 1M5