Status:
COMPLETED
Intracerebral Hemorrhage Acutely Decreasing Arterial Pressure Trial
Lead Sponsor:
University of Alberta
Collaborating Sponsors:
Heart and Stroke Foundation of Canada
Alberta Heritage Foundation for Medical Research
Conditions:
Intracerebral Hemorrhage
Eligibility:
All Genders
18+ years
Phase:
PHASE2
Brief Summary
Rationale: Management of blood pressure (BP) in the acute phase of intracerebral hemorrhage (ICH) remains controversial. Although it has been established that there is a transient moderate reduction o...
Eligibility Criteria
Inclusion
- Age ≥18 years
- Acute primary ICH demonstrated with CT scan
- Onset ≤ 24 h prior to randomization
Exclusion
- Contraindication to BP reduction i.e., severe arterial stenosis or high-grade stenotic valvular heart disease
- Indication for urgent BP reduction i.e., hypertensive encephalopathy, or aortic dissection
- Definite evidence that the ICH is secondary to underlying cerebral or vascular pathology, i.e., AVM, aneurysm, tumour, trauma, vasculitis, or hemorrhagic transformation of an ischemic infarct
- Previous ischemic stroke within 30 days of current event NB: Prior ICH is not an exclusion criterion
- Planned surgical resection of hematoma NB: Extraventricular Drain placement is not an exclusion criterion
- Contraindication to CT perfusion imaging (i.e. contrast allergy, metformin use or Creatinine \>160 μmol/l)
Key Trial Info
Start Date :
January 1 2007
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
February 1 2012
Estimated Enrollment :
74 Patients enrolled
Trial Details
Trial ID
NCT00963976
Start Date
January 1 2007
End Date
February 1 2012
Last Update
February 28 2012
Active Locations (4)
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1
University of Calgary
Calgary, Alberta, Canada
2
University of Alberta
Edmonton, Alberta, Canada, T6G2B7
3
Grey Nuns Hospital
Edmonton, Alberta, Canada, T6L 5X8
4
University of Ottawa
Ottawa, Ontario, Canada